Association of HLA class II alleles with suicidal behavior in a Transylvanian population
نویسندگان
چکیده
Abstract Background : Suicide is a complex phenomenon determined by the interaction of various risk factors. The Major Histocompatibility Complex most polymorphic gene cluster entire human genome, being linked to both regulation immune system and psychiatric diseases. aim this study was identify HLA-DQB1 DRB1 alleles genotypes susceptible influence suicidal behavior. Methods We explored association with behavior on sample 427 individuals (including 110 suicide attempters) from Transylvania, as well HLA-DRB1 271 50 attempters), using single specific primer-PCR (SSP-PCR) technique. Results found that HLA-DQB1*02, *03 *06 alleles, DQB1*02/*03, DQB1*02/*06, DRB1*12/*15 DRB1*07/*13 genotypes, DQB1*06~DRB1*07 DQB1*02~DRB1*13 haplotypes, were more frequent in attempters. In contrast, HLA-DQB1*04 DQB1*13 DQB1*02/*05 DQB1*03/*05 DQB1*03~DRB1*13 haplotype less case group. Conclusion DQB1*02/*03 *02/*06 are favor behavior, while *13 *03/*05 protective against such A similar analysis regarding detected possible for among possessing either or genotypes. haplotypes exhibited influence.
منابع مشابه
Association between HLA-Class I and HLA-Class II Alleles and Mycobacterium Tuberculosis Infection in Iraqi Patients from Baghdad City
Background: Pulmonary tuberculosis (PT) is one of the endemic diseases in Iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (HLA) system. We sought to investigate the association between HLA-class I (A and B) and -class II (DR and DQ) alleles in a sample of PT Iraqi patients.Methods: lymphocytes of 105 PT patients and 40 controls were phenotyped for H...
متن کاملAssociations of Moyamoya patients with HLA class I and class II alleles in the Korean population.
Moyamoya disease is characterized by progressive cerebrovascular occlusion at the peripheral internal carotid artery and development of abnormal collateral circulation at the cerebral basal region. Although abnormal thrombogenesis, inflammation and autoimmune process might be involved in the etiology, the genetic pathogenesis of Moyamoya disease is still unknown. To evaluate the association of ...
متن کاملassociation of hla class ii alleles with childhood asthma and total ige levels
asthma is a complex and multifactorial disorder. several studies have reported association between different hla- dqb1 and hla- drb1 alleles and allergic asthma. the aim of the present study was to investigate the association of hla-class ii alleles and haplotypes, with total serum ige and the results of the skin prick test in iranian children with allergic asthma. a total of 112 patients with ...
متن کاملassociation between hla-class i and hla-class ii alleles and mycobacterium tuberculosis infection in iraqi patients from baghdad city
background: pulmonary tuberculosis (pt) is one of the endemic diseases in iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (hla) system. we sought to investigate the association between hla-class i (a and b) and -class ii (dr and dq) alleles in a sample of pt iraqi patients. methods: lymphocytes of 105 pt patients and 40 controls were phenotyped for ...
متن کاملAssociation of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan.
BACKGROUND Nasopharyngeal carcinoma (NPC), which occurs at a disproportionately high rate among Chinese individuals, is associated with Epstein-Barr virus (EBV). Human leukocyte antigen (HLA) polymorphisms appear to play a role in NPC, because they are essential in the immune response to viruses. We used high-resolution HLA genotyping in a case-control study in Taiwan to systematically evaluate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Romanian Journal of Laboratory Medicine
سال: 2023
ISSN: ['1841-6624', '2284-5623']
DOI: https://doi.org/10.2478/rrlm-2023-0001